Dr. Poulami Khan

Assistant Professor at Department of Biochemistry, Asutosh College

E-mail ID: mail2poulami@gmail.com, poulami.khan@asutoshcollege.in

Academic Qualification:

* PhD: Thesis awarded from University of Calcutta, India. Research experience (Cancer Biology: Epithelial cancer cell signalling, Cancer Stem Cell, Angiogenesis, Drug resistance, Metastasis), 2010-2017, Bose Institute, Kolkata.

* M.Sc. (Biochemistry-Industrial Microbiology & Cancer Immunology special paper), 2006-2008, Calcutta University, Kolkata.

* B.Sc. (Microbiology Major, Chemistry & Physics), 2002-2006 Surendranath College, Calcutta University.

Work Experience:

* 2019- till date: Assistant Professor at Department of Biochemistry, Asutosh College.

* 2018-2019: Post Doctoral Research Fellow at Saroj Gupta Cancer Centre and Research Institute, Thakurpukur.

* 2017-2018: Post Doctoral Research Fellow at Bose Institute, Division of Molecular Medicine.

* 2014-2017: Senior Research Fellow at Bose Institute, Division of Molecular Medicine.

* 2010-2013: Junior Research Fellow at Bose Institute, Division of Molecular Medicine.

List of Publications:

Research Article

Banerjee S, Mukherjee S, Bhattacharya A, Basak U, Chakraborty S, Paul S, Khan P, Jana K, Hazra TK, Das T. Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning.         Free Radic Biol Med. 2020; 152: 152-165.

Bhattacharya A, Mukherjee S, Khan P, Banerjee S, Dutta A, Banerjee N, Sengupta D, Basak U, Chakraborty S, Dutta A, Chattopadhyay S, Jana K, Sarkar DK, Chatterjee S, Das T. SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin. Sci Signal. 2020;13(654):eaay6077. doi: 10.1126/scisignal.aay6077.

Guha D, Saha T, Bose S, Chakraborty S, Dhar S, Khan P, Adhikary A, Das T, Sa G. Integrin-EGFR interaction regulates anoikis resistance in colon cancer cells.Apoptosis. 2019; 24(11-12):958-971.

Khan P, Bhattacharya A, Sengupta D, Banerjee S, Adhikary A, Das T. Aspirin enhances cisplatin sensitivity of resistant non-small cell lung carcinoma stem-like cells by targeting mTOR-Akt axis to repress migration. Sci Rep. 2019;9(1):16913.

Khan P, Manna A, Saha S, Mohanty S, Mukherjee S, Mazumdar M, Guha D, Das T. Aspirin inhibits epithelial-to-mesenchymal transition and migration of K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug. BMC Cancer. 2016; 16(1):39.

Saha S, Mukherjee S, Khan P, Kajal K, Mazumdar M, Manna A, Mukherjee S, De Sunanda, Jana D, Sarkar DK and Das T. Post-chemotherapy generation of aggressive cancer stem cell pool via activation of NFkB-IL-6 feed-back loop: Inhibition by aspirin pre-exposure Cancer Res. 2016 pii: canres.1360.2015. Cancer Res. 2016; 76(7) 2000-2012.

Saha S, Bhattacharjee P, Guha D, Kajal K, Khan P, Chakraborty S, Mukherjee S, Paul S, Manchanda R, Khurana A, Nayak D, Chakrabarty R, Sa G, Das T. Sulphur alters NF?B-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma Int J Onc. 2015, 47:573-582.

Chakraborty S, Mazumdar M, Mukherjee S, Bhattacharjee P, Adhikary A, Manna A, Chakraborty S, Khan P, Sen A, Das T. Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. FEBS Letters. 2014, 588(4):549-559.

Chakraborty S, Das K, Saha S, Mazumdar M, Manna A, Chakraborty S, Mukherjee S, Khan P, Adhikary A, Mohanty S, Chattopadhyaya S, Biswas S, Sa G, Das T. Nuclear matrix protein SMAR1 represses c-Fos mediated HPV18 E6 transcription through alteration of chromatin histone de-acetylation. J Biol Chem. 2014, 289(42):29074-85.

Mukherjee S, Mazumdar M, Chakraborty S, Manna A, Saha S, Khan P, Bhattacharjee P, Guha D, Adhikary A, Mukherjee S, Das T. Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/ ?-catenin negative feedback loop. Stem Cell Research & Therapy. 2014, 5:116.

Saha S, Mukherjee S, Mazumdar M, Manna A, Khan P, Adhikary A, Kajal K, Jana D, Sa G, Mukherjee S, Sarkar DK, Das T. Mithramycin A sensitizes therapy-resistant breast cancer stem cells towards genotoxic drug doxorubicin Translational Res. 2014, 165(5):558-77.

Review

Manna A, Banerjee S, Khan P, Bhattacharya A and Das T. Contribution of nuclear events in generation and maintenance of cancer stem cells: Revisiting chemo-resistance. Nucleus. 2017, doi:10.1007/s13237-017-0193-8. 1-15.

Basak U, Dutta A, Dutta Chowdhury D, Bhattacharya A, Banerjee S, Khan P and Das T. Deciphering the cancer puzzle: Cancer stem cells being the pivotal piece. J Stem Cell Res Transplant.2017, 4(1):1-11.

Das A, Dutta A, Paul S, Dutta A, Bhattacharya A, Banerjee S, Dutta Chowdhury D, Basak U, Khan P, Mazumdar D and Das T. Cancer stem cells, their origin and niche: A search for the therapeutic target. J Stem Cell Res Med. 2017, 2(1):1-11.

Book Chapter

Proteolytic Networks at the Crossroads of Cancer Cell Life and Death: Cancer Stem Cell Deciding Cell Fate. Khan P, Banerjee S, Bhattacharya A, Dutta A and Das T. Pathophysiological aspects of proteases. Springer publication. doi: 10.1007/978-981-10-6141-7_11.

List of Award Received:

Awarded for best poster (2017) at Bose Institute, India.

Qualified joint CSIR-UGC National Eligibility Test (NET), 2009 for Junior Research Fellowship in Life Science.

Qualified joint CSIR-UGC National Eligibility Test (NET), 2009 for Lectureship in Life Science.

Qualified Graduate Aptitude Test in Engineering (GATE-2009) in Biotechnology, conducted by Indian Institute of Science (IISc), Bangalore, India.

Membership of Learned Societies:

Life Membership of Society of Biological Chemists, India.

Membership of Kolkata Gynaecological Oncology Trials and Translational Research.